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Characterization of Ectromelia Virus Deficient in EVM036, the Homolog of Vaccinia virus F13L, and Its Application for Rapid Generation of Recombinant Viruses

The orthopoxvirus (OPV) vaccinia virus (VACV) requires an intact F13L gene to produce enveloped virions (EV) and to form plaques in cell monolayers. Simultaneous introduction of an exogenous gene and F13L into F13L-deficient VACV results in expression of the foreign gene and restoration of plaque si...

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Detalhes bibliográficos
Main Authors: Roscoe, Felicia, Xu, Ren-Huan, Sigal, Luis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503138/
https://ncbi.nlm.nih.gov/pubmed/23035222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01732-12
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