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Locating a Plausible Binding Site for an Open-Channel Blocker, GlyH-101, in the Pore of the Cystic Fibrosis Transmembrane Conductance Regulator

High-throughput screening has led to the identification of small-molecule blockers of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, but the structural basis of blocker binding remains to be defined. We developed molecular models of the CFTR channel on the basis of...

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Autors principals: Norimatsu, Yohei, Ivetac, Anthony, Alexander, Christopher, O'Donnell, Nicolette, Frye, Leah, Sansom, Mark S. P., Dawson, David C.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502623/
https://ncbi.nlm.nih.gov/pubmed/22923500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080267
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