Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes.

Tetrahymena pyriformis, Neurospora crassa, and Aspergillus fumigatus that had been grown in simple defined media were extracted with acid ethanol by a classic method for recovering insulin from pancreas. After filtration of the extracts on Sephadex G-50, distinct peaks of insulin immunoreactivity we...

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Main Authors: Le Roith, D, Shiloach, J, Roth, J, Lesniak, M A
Format: Artigo
Sprog:Inglês
Udgivet: 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC350239/
https://ncbi.nlm.nih.gov/pubmed/6449704
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