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Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes.

Tetrahymena pyriformis, Neurospora crassa, and Aspergillus fumigatus that had been grown in simple defined media were extracted with acid ethanol by a classic method for recovering insulin from pancreas. After filtration of the extracts on Sephadex G-50, distinct peaks of insulin immunoreactivity we...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Le Roith, D, Shiloach, J, Roth, J, Lesniak, M A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1980
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350239/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6449704/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.10.6184
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