Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes.

Tetrahymena pyriformis, Neurospora crassa, and Aspergillus fumigatus that had been grown in simple defined media were extracted with acid ethanol by a classic method for recovering insulin from pancreas. After filtration of the extracts on Sephadex G-50, distinct peaks of insulin immunoreactivity we...

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Bibliographic Details
Main Authors: Le Roith, D, Shiloach, J, Roth, J, Lesniak, M A
Format: Artigo
Language:Inglês
Published: 1980
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC350239/
https://ncbi.nlm.nih.gov/pubmed/6449704
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