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Histone Deacetylase (HDAC) 1 Controls the Expression of Beta Defensin 1 in Human Lung Epithelial Cells

Deregulation of the expression human beta defensin 1 (DEFB1), an antimicrobial peptide, has been implicated in the pathogenesis of COPD and asthma. Since the molecular mechanisms that regulate DEFB1 gene expression are widely unknown, the epigenetic processes involved in the regulation of the consti...

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Autors principals: Kallsen, Kimberley, Andresen, Ellen, Heine, Holger
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502185/
https://ncbi.nlm.nih.gov/pubmed/23185513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050000
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