Anti-Gr-1 antibody depletion fails to eliminate hepatic myeloid-derived suppressor cells in tumor-bearing mice

Recent studies show that the liver is a preferred organ for the accumulation of MDSC. In this study, we examined the effect of systemic RB6-8C5 treatment on hepatic MDSC in tumor-bearing mice. EL4 tumor-bearing mice were injected i.p. with RB6-8C5, and hepatic, splenic, and blood MDSCs were analyzed...

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Bibliographic Details
Main Authors: Ma, Chi, Kapanadze, Tamar, Gamrekelashvili, Jaba, Manns, Michael P., Korangy, Firouzeh, Greten, Tim F.
Format: Artigo
Language:Inglês
Published: Society for Leukocyte Biology 2012
Subjects:
Cell Development, Differentiation, & Trafficking
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501895/
https://ncbi.nlm.nih.gov/pubmed/23077247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0212059
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