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IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model

Much remains to be learned regarding which components of the innate immune response are protective versus detrimental during sepsis. Prior reports demonstrated that TLR9 and MyD88 play key roles in the CLP mouse model of sepsis; however, the role of additional PRRs and their signaling intermediates...

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Autori principali: Walker, Wendy E., Bozzi, Aaron T., Goldstein, Daniel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Leukocyte Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501894/
https://ncbi.nlm.nih.gov/pubmed/23048204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0312138
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