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Protein kinase D-HDAC5 signaling regulates erythropoiesis and contributes to erythropoietin cross-talk with GATA1

In red cell development, the differentiation program directed by the transcriptional regulator GATA1 requires signaling by the cytokine erythropoietin, but the mechanistic basis for this signaling requirement has remained unknown. Here we show that erythropoietin regulates GATA1 through protein kina...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Delehanty, Lorrie L., Bullock, Grant C., Goldfarb, Adam N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501719/
https://ncbi.nlm.nih.gov/pubmed/22983445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-387050
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