Hereditary Hemochromatosis Restores the Virulence of Plague Vaccine Strains

Nonpigmented Yersinia pestis (pgm) strains are defective in scavenging host iron and have been used in live-attenuated vaccines to combat plague epidemics. Recently, a Y. pestis pgm strain was isolated from a researcher with hereditary hemochromatosis who died from laboratory-acquired plague. We use...

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Dettagli Bibliografici
Autori principali: Quenee, Lauriane E., Hermanas, Timothy M., Ciletti, Nancy, Louvel, Helene, Miller, Nathan C., Elli, Derek, Blaylock, Bill, Mitchell, Anthony, Schroeder, Jay, Krausz, Thomas, Kanabrocki, Joseph, Schneewind, Olaf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501692/
https://ncbi.nlm.nih.gov/pubmed/22896664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis433
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