Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis

MAGI-1, a member of the MAGUK family of proteins, is shown to be rapidly cleaved during Fas-induced apoptosis in mouse 3T3 A31 cells, and in UV irradiation- and staurosporine-induced apoptosis in HaCaT cells. This generates a 97 kDa N-terminal fragment that dissociates from the cell membrane; a proc...

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Hauptverfasser: Gregorc, Uros, Ivanova, Saska, Thomas, Miranda, Guccione, Ernesto, Glaunsinger, Britt, Javier, Ron, Turk, Vito, Banks, Lawrence, Turk, Boris
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501654/
https://ncbi.nlm.nih.gov/pubmed/17191119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-006-0579-6
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