SATB1 Cleavage by Caspase 6 Disrupts PDZ Domain-Mediated Dimerization, Causing Detachment from Chromatin Early in T-Cell Apoptosis

SATB1 is expressed primarily in thymocytes and orchestrates temporal and spatial expression of a large number of genes in the T-cell lineage. SATB1 binds to the bases of chromatin loop domains in vivo, recognizing a special DNA context with strong base-unpairing propensity. The majority of thymocyte...

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Detalhes bibliográficos
Main Authors: Galande, Sanjeev, Dickinson, Liliane A., Mian, I. Saira, Sikorska, Marianna, Kohwi-Shigematsu, Terumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87280/
https://ncbi.nlm.nih.gov/pubmed/11463840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5591-5604.2001
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