The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis

Weibel-Palade body (WPB) exocytosis underlies hormone-evoked VWF secretion from endothelial cells (ECs). We identify new endogenous components of the WPB: Rab3B, Rab3D, and the Rab27A/Rab3 effector Slp4-a (granuphilin), and determine their role in WPB exocytosis. We show that Rab3B, Rab3D, and Rab27...

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Autors principals: Bierings, Ruben, Hellen, Nicola, Kiskin, Nikolai, Knipe, Laura, Fonseca, Ana-Violeta, Patel, Bijal, Meli, Athina, Rose, Marlene, Hannah, Matthew J., Carter, Tom
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Vascular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501642/
https://ncbi.nlm.nih.gov/pubmed/22898601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-429936
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