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The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T-cell development and malignancy
The TCF-1 and LEF-1 transcription factors are known to play critical roles in normal thymocyte development. Unexpectedly, we found that TCF-1-deficient (Tcf7(−/−)) mice developed aggressive T-cell malignancy, resembling human T-cell acute lymphoblastic leukemia (T-ALL). Surprisingly, LEF-1 was aberr...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501598/ https://ncbi.nlm.nih.gov/pubmed/23103132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.08.009 |
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