The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T-cell development and malignancy

The TCF-1 and LEF-1 transcription factors are known to play critical roles in normal thymocyte development. Unexpectedly, we found that TCF-1-deficient (Tcf7(−/−)) mice developed aggressive T-cell malignancy, resembling human T-cell acute lymphoblastic leukemia (T-ALL). Surprisingly, LEF-1 was aberr...

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Detalhes bibliográficos
Main Authors: Yu, Shuyang, Zhou, Xinyuan, Steinke, Farrah C., Liu, Chengyu, Chen, Shann-Ching, Zagorodna, Oksana, Jing, Xuefang, Yokota, Yoshifumi, Meyerholz, David K., Mullighan, Charles G., Knudson, C. Michael, Zhao, Dong-Mei, Xue, Hai-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501598/
https://ncbi.nlm.nih.gov/pubmed/23103132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.08.009
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