Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist

Hyperglucagonemia is implicated in the pathophysiology of hyperglycemia. Antagonism of the glucagon receptor (GCGR) thus represents a potential approach to diabetes treatment. Herein we report the characterization of GRA1, a novel small-molecule GCGR antagonist that blocks glucagon binding to the hu...

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Main Authors: Mu, James, Qureshi, Sajjad A., Brady, Edward J., Muise, Eric S., Candelore, Mari Rios, Jiang, Guoqiang, Li, Zhihua, Wu, Margaret S., Yang, Xiaodong, Dallas-Yang, Qing, Miller, Corey, Xiong, Yusheng, Langdon, Ronald B., Parmee, Emma R., Zhang, Bei B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2012
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501516/
https://ncbi.nlm.nih.gov/pubmed/23185367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049572
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