Congenital B cell lymphocytosis explained by novel germline CARD11 mutations

Nuclear factor-κB (NF-κB) controls genes involved in normal lymphocyte functions, but constitutive NF-κB activation is often associated with B cell malignancy. Using high-throughput whole transcriptome sequencing, we investigated a unique family with hereditary polyclonal B cell lymphocytosis. We fo...

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Detalhes bibliográficos
Main Authors: Snow, Andrew L., Xiao, Wenming, Stinson, Jeffrey R., Lu, Wei, Chaigne-Delalande, Benjamin, Zheng, Lixin, Pittaluga, Stefania, Matthews, Helen F., Schmitz, Roland, Jhavar, Sameer, Kuchen, Stefan, Kardava, Lela, Wang, Wei, Lamborn, Ian T., Jing, Huie, Raffeld, Mark, Moir, Susan, Fleisher, Thomas A., Staudt, Louis M., Su, Helen C., Lenardo, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501355/
https://ncbi.nlm.nih.gov/pubmed/23129749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120831
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