Clinical characterization and mitochondrial DNA sequence variations in Leber hereditary optic neuropathy

PURPOSE: Leber hereditary optic neuropathy (LHON), a maternally inherited disorder, results from point mutations in mitochondrial DNA (mtDNA). MtDNA is highly polymorphic in nature with very high mutation rate, 10–17 fold higher as compared to nuclear genome. Identification of new mtDNA sequence var...

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Bibliografske podrobnosti
Main Authors: Kumar, Manoj, Kaur, Punit, Saxena, Rohit, Sharma, Pradeep, Dada, Rima
Format: Artigo
Jezik:Inglês
Izdano: Molecular Vision 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501276/
https://ncbi.nlm.nih.gov/pubmed/23170061
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