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Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment

Premature senescence, a key strategy used to suppress carcinogenesis, can be driven by p53/p21 proteins in response to various stresses. Here, we demonstrate that Wig1 plays a critical role in this process through regulation of p21 mRNA stability. Wig1 controls the association of Argonaute2 (Ago2),...

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Detalhes bibliográficos
Main Authors: Kim, Bong Cho, Lee, Hyung Chul, Lee, Je-Jung, Choi, Chang-Min, Kim, Dong-Kwan, Lee, Jae Cheol, Ko, Young-Gyu, Lee, Jae-Seon
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501221/
https://ncbi.nlm.nih.gov/pubmed/23085987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.286
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