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Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment
Premature senescence, a key strategy used to suppress carcinogenesis, can be driven by p53/p21 proteins in response to various stresses. Here, we demonstrate that Wig1 plays a critical role in this process through regulation of p21 mRNA stability. Wig1 controls the association of Argonaute2 (Ago2),...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
European Molecular Biology Organization
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501221/ https://ncbi.nlm.nih.gov/pubmed/23085987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.286 |
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