Cholesterol Accumulation Regulates the Expression of Macrophage Proteins Implicated In Proteolysis and Complement Activation

OBJECTIVE: Cholesterol accumulation by macrophages plays a key role in atherogenesis. To begin to develop a global picture of this process, we used proteomics and transcriptomics to analyze foam cells generated with acetyl-LDL, a classic ligand for scavenger receptors. METHODS AND RESULTS: Tandem ma...

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Main Authors: Suzuki, Masashi, Becker, Lev, Pritchard, David K., Gharib, Sina A., Wijsman, Ellen, Bammler, Theo K., Beyer, Richard P., Vaisar, Tomas, Oram, John F., Heinecke, Jay W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501207/
https://ncbi.nlm.nih.gov/pubmed/23042816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300383
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