Diversification of the Structural Determinants of Fibroblast Growth Factor-Heparin Interactions: IMPLICATIONS FOR BINDING SPECIFICITY

The functions of a large number (>435) of extracellular regulatory proteins are controlled by their interactions with heparan sulfate (HS). In the case of fibroblast growth factors (FGFs), HS binding determines their transport between cells and is required for the assembly of high affinity signal...

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Bibliographic Details
Main Authors: Xu, Ruoyan, Ori, Alessandro, Rudd, Timothy R., Uniewicz, Katarzyna A., Ahmed, Yassir A., Guimond, Scott E., Skidmore, Mark A., Siligardi, Giuliano, Yates, Edwin A., Fernig, David G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501079/
https://ncbi.nlm.nih.gov/pubmed/23019343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398826
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