Substrate-bound Crystal Structures Reveal Features Unique to Mycobacterium tuberculosis N-Acetyl-glucosamine 1-Phosphate Uridyltransferase and a Catalytic Mechanism for Acetyl Transfer

N-Acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), a bifunctional enzyme involved in bacterial cell wall synthesis is exclusive to prokaryotes. GlmU, now recognized as a promising target to develop new antibacterial drugs, catalyzes two key reactions: acetyl transfer and uridyl transfer at t...

Full description

Saved in:
Bibliographic Details
Main Authors: Jagtap, Pravin Kumar Ankush, Soni, Vijay, Vithani, Neha, Jhingan, Gagan Deep, Bais, Vaibhav Singh, Nandicoori, Vinay Kumar, Prakash, Balaji
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501063/
https://ncbi.nlm.nih.gov/pubmed/22969087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.390765
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items