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Metabolic Inhibition of Sialyl-Lewis X Biosynthesis by 5-Thiofucose Remodels the Cell Surface and Impairs Selectin-Mediated Cell Adhesion

Sialyl-Lewis X (sLe(X)) is a tetrasaccharide that serves as a ligand for the set of cell adhesion proteins known as selectins. This interaction enables adhesion of leukocytes and cancer cells to endothelial cells within capillaries, resulting in their extravasation into tissues. The last step in sLe...

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Библиографические подробности
Главные авторы: Zandberg, Wesley F., Kumarasamy, Jayakanthan, Pinto, B. Mario, Vocadlo, David J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501042/
https://ncbi.nlm.nih.gov/pubmed/23019334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.403568
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