Distinct Roles of the C-terminal 11th Transmembrane Helix and Luminal Extension in the Partial Reactions Determining the High Ca(2+) Affinity of Sarco(endo)plasmic Reticulum Ca(2+)-ATPase Isoform 2b (SERCA2b)

The molecular mechanism underlying the characteristic high apparent Ca(2+) affinity of SERCA2b relative to SERCA1a and SERCA2a isoforms was studied. The C-terminal tail of SERCA2b consists of an 11th transmembrane helix (TM11) with an associated 11-amino acid luminal extension (LE). The effects of e...

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Hlavní autoři: Clausen, Johannes D., Vandecaetsbeek, Ilse, Wuytack, Frank, Vangheluwe, Peter, Andersen, Jens Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501024/
https://ncbi.nlm.nih.gov/pubmed/23024360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.397331
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