Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin

The cholesterol-dependent cytolysins (CDCs) attack cells by punching large holes in their membranes. Lectinolysin from Streptococcus mitis is unique among CDCs due to the presence of an N-terminal lectin domain that enhances the pore-forming activity of the toxin. We recently determined the crystal...

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Main Authors: Lawrence, Sara L., Feil, Susanne C., Holien, Jessica K., Kuiper, Michael J., Doughty, Larissa, Dolezal, Olan, Mulhern, Terrence D., Tweten, Rodney K., Parker, Michael W.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2012
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500998/
https://ncbi.nlm.nih.gov/pubmed/23181061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00330
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