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ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na(+)/K(+)ATPase
Here, we describe a phosphorylation-based reverse myristoyl switch for mammalian ZNRF2, and show that this E3 ubiquitin ligase and its sister protein ZNRF1 regulate the Na(+)/K(+) pump (Na(+)/K(+)ATPase). N-myristoylation localizes ZNRF1 and ZNRF2 to intracellular membranes and enhances their activi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500867/ https://ncbi.nlm.nih.gov/pubmed/22797923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.110296 |
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