Tumour necrosis factor alpha downregulates human hemojuvelin expression via a novel response element within its promoter

BACKGROUND: Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been identified as a main upstream regulator of hepcidin expression; HJV mutations ar...

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Autors principals: Salama, Mohamed Fouda, Bayele, Henry K, Srai, Surjit SK
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500654/
https://ncbi.nlm.nih.gov/pubmed/22998440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-19-83
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