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Tumour necrosis factor alpha downregulates human hemojuvelin expression via a novel response element within its promoter
BACKGROUND: Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been identified as a main upstream regulator of hepcidin expression; HJV mutations ar...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500654/ https://ncbi.nlm.nih.gov/pubmed/22998440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-19-83 |
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