Mutations in Isocitrate Dehydrogenase 1 and 2 Occur Frequently in Intrahepatic Cholangiocarcinomas and Share Hypermethylation Targets with Glioblastomas

Mutations in the genes encoding isocitrate dehydrogenase, IDH1 and IDH2, have been reported in gliomas, myeloid leukemias, chondrosarcomas, and thyroid cancer. We discovered IDH1 and IDH2 mutations in 34 of 326 (10%) intrahepatic cholangiocarcinomas. Tumor with mutations in IDH1 or IDH2 had lower 5-...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Wang, Pu, Dong, Qiongzhu, Zhang, Chong, Kuan, Pei-Fen, Liu, Yufeng, Jeck, William R., Andersen, Jesper B., Jiang, Wenqing, Savich, Gleb L., Tan, Ting-Xu, Auman, J. Todd, Hoskins, Janelle M., Misher, Anne D., Moser, Catherine D., Yourstone, Scott M., Kim, Jin Woo, Cibulskis, Kristian, Getz, Gad, Hunt, Heike V., Thorgeirsson, Snorri S., Roberts, Lewis R., Ye, Dan, Guan, Kun-Liang, Xiong, Yue, Qin, Lun-Xiu, Chiang, Derek Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500578/
https://ncbi.nlm.nih.gov/pubmed/22824796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.315
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares