The Autophagy-Senescence Connection in Chemotherapy: Must Tumor Cells (Self) Eat Before They Sleep?

Exposure of MCF-7 breast tumor cells or HCT-116 colon carcinoma cells to clinically relevant concentrations of doxorubicin (Adriamycin; Farmitalia Research Laboratories, Milan, Italy) or camptothecin results in both autophagy and senescence. To determine whether autophagy is required for chemotherap...

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Detalhes bibliográficos
Main Authors: Goehe, Rachel W., Di, Xu, Sharma, Khushboo, Bristol, Molly L., Henderson, Scott C., Valerie, Kristoffer, Rodier, Francis, Davalos, Albert R., Gewirtz, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Cellular and Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500537/
https://ncbi.nlm.nih.gov/pubmed/22927544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.197590
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