Dual functions of autophagy in the response of breast tumor cells to radiation: Cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D(3)

In MCF-7 breast tumor cells, ionizing radiation promoted autophagy that was cytoprotective; pharmacological or genetic interference with autophagy induced by radiation resulted in growth suppression and/or cell killing (primarily by apoptosis). The hormonally active form of vitamin D, 1,25D(3), also...

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Detalhes bibliográficos
Main Authors: Bristol, Molly L., Di, Xu, Beckman, Matthew J., Wilson, Eden N., Henderson, Scott C., Maiti, Aparna, Fan, Zhen, Gewirtz, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378418/
https://ncbi.nlm.nih.gov/pubmed/22498493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.19313
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