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Loss of the Par3 Polarity Protein Promotes Breast Tumorigenesis and Metastasis
Loss of epithelial organization is a hallmark of carcinomas, but whether polarity regulates tumor growth and metastasis is poorly understood. To address this issue we depleted the Par3 polarity gene by RNAi in combination with oncogenic Notch or Ras(61L) expression in the murine mammary gland. Par3...
में बचाया:
| मुख्य लेखकों: | , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500525/ https://ncbi.nlm.nih.gov/pubmed/23153534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.10.003 |
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