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Synthetic Allergen Design Reveals The Significance of Moderate Affinity Epitopes in Mast Cell Degranulation
This study describes the design of a well-defined homotetravalent synthetic allergen (HTA) system to investigate the effect of hapten-IgE interactions on mast cell degranulation. A library of DNP-variants with varying affinities for IgE(DNP) was generated (K(d)s 8.1 nM – 9.2 µM), and 8 HTAs spanning...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500431/ https://ncbi.nlm.nih.gov/pubmed/22877585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300193f |
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