p21-activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model

The RAS genes are the most commonly mutated oncogenes in human cancer and present a particular therapeutic dilemma, as direct targeting of Ras proteins by small molecules has proved difficult. Signaling pathways downstream of Ras, in particular Raf/Mek/Erk and PI3K/Akt/mTOR, are dominated by lipid a...

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Detalhes bibliográficos
Main Authors: Chow, H.Y., Jubb, A.M., Koch, J.N., Jaffer, Z.M., Stepanova, D., Campbell, D.A., Duron, S. G., O'Farrell, M., Cai, Q., Klein-Szanto, A.J., Gutkind, J.S., Hoeflich, K.P., Chernoff, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500416/
https://ncbi.nlm.nih.gov/pubmed/22983922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2246
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