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Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content

Alterations in lipid homeostasis are implicated in several neurodegenerative diseases, although the mechanisms responsible are poorly understood. We evaluated the impact of cholesterol accumulation, induced by U18666A, quinacrine or mutations in the cholesterol transporting Niemann-Pick disease type...

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Main Authors: Appelqvist, Hanna, Sandin, Linnea, Björnström, Karin, Saftig, Paul, Garner, Brett, Öllinger, Karin, Kågedal, Katarina
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500374/
https://ncbi.nlm.nih.gov/pubmed/23166840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050262
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