BCL::Fold - De Novo Prediction of Complex and Large Protein Topologies by Assembly of Secondary Structure Elements

Computational de novo protein structure prediction is limited to small proteins of simple topology. The present work explores an approach to extend beyond the current limitations through assembling protein topologies from idealized α-helices and β-strands. The algorithm performs a Monte Carlo Metrop...

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Bibliographic Details
Main Authors: Karakaş, Mert, Woetzel, Nils, Staritzbichler, Rene, Alexander, Nathan, Weiner, Brian E., Meiler, Jens
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500284/
https://ncbi.nlm.nih.gov/pubmed/23173050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049240
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