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Identification of functional DNA variants in the constitutive promoter region of MDM2
Although mutations in the oncoprotein murine double minute 2 (MDM2) are rare, MDM2 gene overexpression has been observed in several human tumors. Given that even modest changes in MDM2 levels might influence the p53 tumor suppressor signaling pathway, we postulated that sequence variation in the pro...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500213/ https://ncbi.nlm.nih.gov/pubmed/23244604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-7364-6-15 |
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