Variants in the 3′UTR of SNCA do not affect miRNA-433 binding and alpha-synuclein expression

Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD) and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. Regulatory regions relevant for SNCA expression include the 3′ untranslated region (UTR), which among other regulatory elements contai...

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Main Authors: Schmitt, Ina, Wüllner, Ullrich, van Rooyen, Jan Pierre, Khazneh, Hassan, Becker, Julian, Volk, Alexander, Kubisch, Christian, Becker, Tim, Kostic, Vladimir S, Klein, Christine, Ramirez, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499742/
https://ncbi.nlm.nih.gov/pubmed/22617348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2012.84
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