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Alpha‐synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3ʹUTR
BACKGROUND: Multiple variants in SNCA, encoding alpha‐synuclein, a main component of Lewy bodies, are implicated in Parkinson's disease. METHODS: We searched for cis‐acting SNCA variants using allelic mRNA ratios in human brain tissues. In a SNCA 3′UTR (2,520 bp) luciferase reporter gene assay,...
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| Publicado no: | Mol Genet Genomic Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6081226/ https://ncbi.nlm.nih.gov/pubmed/29730891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mgg3.407 |
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