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Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis
Castration-resistant prostate cancer (PCa) is refractory to hormone therapy and new strategies for treatment are urgently needed. We found that androgen-insensitive (AI) PCa cells, LNCaP-AI, are reprogrammed to upregulate the mitotic kinase Plk1 and other M phase cell cycle proteins, which may under...
Gorde:
| Egile Nagusiak: | , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2012
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3499666/ https://ncbi.nlm.nih.gov/pubmed/22890325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.309 |
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