Animal model for immune dysfunction associated with adenosine deaminase deficiency.

An in vivo murine model for immunodeficiency of both B and T cells is produced by continuous intraperitoneal infusion of 2'-deoxycoformycin (DCF), a specific tightly binding inhibitor of adenosine deaminase (ADase; adenosine aminohydrolase, EC 3.5.4.4). After DCF infusion, ADase of thymus, sple...

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Autores principales: Tedde, A, Balis, M E, Ikehara, S, Pahwa, R, Good, R A, Trotta, P P
Formato: Artigo
Lenguaje:Inglês
Publicado: 1980
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC349956/
https://ncbi.nlm.nih.gov/pubmed/6968908
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