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A Novel Interplay between Rap1 and PKA Regulates Induction of Angiogenesis in Prostate Cancer
Angiogenesis inhibition is an important therapeutic strategy for advanced stage prostate cancer. Previous work from our laboratory showed that sustained stimulation of Rap1 by 8-pCPT-2'-O-Me-cAMP (8CPT) via activation of Epac, a Rap1 GEF, or by expression of a constitutively active Rap1 mutant...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3499522/ https://ncbi.nlm.nih.gov/pubmed/23166790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049893 |
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