Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies

BACKGROUND: The discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites. The anti-trypanosomal activity relies on perturbing the highly active recycling of the Variant-specific Surfac...

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Bibliografiske detaljer
Main Authors: Caljon, Guy, Stijlemans, Benoît, Saerens, Dirk, Van Den Abbeele, Jan, Muyldermans, Serge, Magez, Stefan, De Baetselier, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499403/
https://ncbi.nlm.nih.gov/pubmed/23166849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001902
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