High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface...

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Bibliographische Detailangaben
Hauptverfasser: Stijlemans, Benoît, Caljon, Guy, Natesan, Senthil Kumar A., Saerens, Dirk, Conrath, Katja, Pérez-Morga, David, Skepper, Jeremy N., Nikolaou, Alexandros, Brys, Lea, Pays, Etienne, Magez, Stefan, Field, Mark C., De Baetselier, Patrick, Muyldermans, Serge
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116811/
https://ncbi.nlm.nih.gov/pubmed/21698216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002072
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