High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface...

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Detalhes bibliográficos
Main Authors: Stijlemans, Benoît, Caljon, Guy, Natesan, Senthil Kumar A., Saerens, Dirk, Conrath, Katja, Pérez-Morga, David, Skepper, Jeremy N., Nikolaou, Alexandros, Brys, Lea, Pays, Etienne, Magez, Stefan, Field, Mark C., De Baetselier, Patrick, Muyldermans, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116811/
https://ncbi.nlm.nih.gov/pubmed/21698216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002072
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