High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface...

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Autors principals: Stijlemans, Benoît, Caljon, Guy, Natesan, Senthil Kumar A., Saerens, Dirk, Conrath, Katja, Pérez-Morga, David, Skepper, Jeremy N., Nikolaou, Alexandros, Brys, Lea, Pays, Etienne, Magez, Stefan, Field, Mark C., De Baetselier, Patrick, Muyldermans, Serge
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116811/
https://ncbi.nlm.nih.gov/pubmed/21698216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002072
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