Integrin αvβ3 and CD44 pathways in metastatic prostate cancer cells support osteoclastogenesis via a Runx2/Smad 5/receptor activator of NF-κB ligand signaling axis

BACKGROUND: Bone loss and pathological fractures are common skeletal complications associated with androgen deprivation therapy and bone metastases in prostate cancer patients. We have previously demonstrated that prostate cancer cells secrete receptor activator of NF-kB ligand (RANKL), a protein es...

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Autores principales: Gupta, Aditi, Cao, Wei, Chellaiah, Meenakshi A
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499378/
https://ncbi.nlm.nih.gov/pubmed/22966907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-66
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