Heterogeneous epigenetic regulation of TIMP3 in prostate cancer

Tissue inhibitor of metalloproteinase-3 (TIMP3) is a tumor suppressor gene frequently downregulated in prostate cancer. The mechanisms involved in TIMP3 transcriptional repression are not fully understood, but evidence suggests that promoter hypermethylation may not be the predominant epigenetic alt...

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Bibliographic Details
Main Authors: Shinojima, Toshiaki, Yu, Qiang, Huang, Sharon K., Li, Michelle, Mizuno, Ryuichi, Liu, Edison T., Hoon, Dave S.B., Lessard, Laurent
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499329/
https://ncbi.nlm.nih.gov/pubmed/23023649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.22333
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