Topoisomerase II alpha gene amplification is a favorable prognostic factor in patients with HER2-positive metastatic breast cancer treated with trastuzumab

BACKGROUND: The vast majority of patients with HER2-positive metastatic breast cancer (MBC) treated with trastuzumab eventually develop resistance to this agent. There is an unmet need therefore, for identifying biological markers with possible prognostic/predictive value in such patients. The aim o...

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Main Authors: Fountzilas, George, Christodoulou, Christos, Bobos, Mattheos, Kotoula, Vassiliki, Eleftheraki, Anastasia G, Xanthakis, Ioannis, Batistatou, Anna, Pentheroudakis, George, Xiros, Nikolaos, Papaspirou, Irene, Koumarianou, Anna, Papakostas, Pavlos, Bafaloukos, Dimitrios, Skarlos, Dimosthenis V, Kalogeras, Konstantine T
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499161/
https://ncbi.nlm.nih.gov/pubmed/23092535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-212
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