TGF-β modulates the functionality of tumor-infiltrating CD8(+) T cells through effects on TCR signaling and Spred1 expression

This study demonstrates that CD8(+) T cells in the tumor microenvironment display reduced functionality and hyporesponsiveness. TGF-β contributed markedly to the tumor-infiltrating CD8(+) T cells’ (TILs) reduced functionality, which could be reversed using a small molecule TGF-β inhibitor. Upon T-ce...

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Detalhes bibliográficos
Main Authors: di Bari, Maria Giovanna, Lutsiak, M. E. Christine, Takai, Shinji, Mostböck, Sven, Farsaci, Benedetto, Tolouei Semnani, Roshanak, Wakefield, Lalage M., Schlom, Jeffrey, Sabzevari, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2009
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499107/
https://ncbi.nlm.nih.gov/pubmed/19319531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-009-0692-9
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