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Identifying therapeutic targets in a combined EGFR–TGFβR signalling cascade using a multiscale agent-based cancer model
Applying a previously developed non-small cell lung cancer model, we assess ‘cross-scale’ the therapeutic efficacy of targeting a variety of molecular components of the epidermal growth factor receptor (EGFR) signalling pathway. Simulation of therapeutic inhibition and amplification allows for the r...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3499073/ https://ncbi.nlm.nih.gov/pubmed/21147846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/imammb/dqq023 |
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