Glucocorticoid-loaded core-crosslinked polymeric micelles with tailorable release kinetics for targeted rheumatoid arthritis therapy

To achieve highly effective glucocorticoid targeting for rheumatoid arthritis therapy, novel, polymerizable and hydrolytically cleavable dexamethasone (DEX) derivatives were covalently entrapped in core-crosslinked polymeric micelles. By varying the oxidation degree of the thioether in the drug link...

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Autori principali: Crielaard, Bart J., Rijcken, Cristianne J.F., Quan, Lingdong, van der Wal, Steffen, Altintas, Isil, van der Pot, Martin, Kruijtzer, John A.W., Liskamp, Rob M.J., Schiffelers, Raymond M., van Nostrum, Cornelus F., Hennink, Wim E., Wang, Dong, Lammers, Twan, Storm, Gert
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499037/
https://ncbi.nlm.nih.gov/pubmed/22692876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201202713
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