Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures

Putative cancer stem cells have been identified in glioblastoma (GBM), associated with resistance to conventional therapies. Overcoming this resistance is a major challenge to manage this deadly brain tumor. Epidermal growth factor receptor (EGFR) is commonly amplified, over-expressed, and/or mutate...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Eimer, Sandrine, Dugay, Frédéric, Airiau, Kelly, Avril, Tony, Quillien, Véronique, Belaud-Rotureau, Marc-Antoine, Belloc, Francis
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2012
Gaiak:
Basic and Translational Investigations
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499019/
https://ncbi.nlm.nih.gov/pubmed/23104476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos266
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